Music network MTV said the Irish rockers will perform in front of the Brandenburg Gate on Nov. 5 during the MTV Europe Music Awards
The show will be beamed into the awards ceremony at Berlin’s O2 World arena.
U2 manager Paul McGuinness said it would be exciting to be in Berlin, “20 years almost to the day since the wall came down.”
The wall fell Nov. 9, 1989, ending almost 30 years of separation between east and west.
U2’s 1991 album Achtung Baby was partly inspired by the band’s stay in the city.
Tickets for the show are available through the http://www.u2.com and http://www.mtvema.com websites from 0800 GMT (4 a.m. EDT) Wednesday.