The Rock and Roll Hall of Famer's manager David Spero says Betts' wife, Donna, has a staph infection and will require surgery followed by home care.
That's forced Betts and his band Great Southern to postpone five dates. Spero says they will be rescheduled at a time to be determined later.
Betts is a pioneering blues rock guitarist and a founding member of The Allman Brothers Band.
Spero says the family will learn more about Donna Betts' outlook in the coming days.